The lidocaine patch 5% was applied in various ways across different studies, primarily focusing on areas of maximal pain such as the knee, intact skin regions for conditions like postherpetic neuralgia (PHN), or chronic pain sites. Application frequency ranged from once daily to twice daily, with a maximum of four patches (560 cm²) per day. The patches were used alongside existing analgesic regimens without dose adjustments, demonstrating good tolerability and no serious adverse effects. Studies included open-label, non-randomized trials and evaluations of pain qualities using tools like the Neuropathic Pain Scale (NPS).
Key Points Explained:
-
Application Site
- The lidocaine patch 5 percent was applied to the area of maximal pain, such as the knee or intact skin regions (avoiding blistered areas in PHN cases).
- For chronic pain conditions (PHN, diabetic neuropathy, low-back pain), patches covered as much of the painful region as possible.
-
Frequency and Duration
- Most studies applied patches once daily, with a maximum of four patches (560 cm²) per day.
- One study used patches twice daily at 12-hour intervals for 2 consecutive days, suggesting variability based on condition and protocol.
-
Study Design
- Trials were open-label, non-randomized, and prospective, conducted across multiple U.S. sites.
- Duration typically spanned 2 weeks, with consistent patch changes every 24 hours in longer studies.
-
Concurrent Analgesic Use
- Patients maintained their existing analgesic regimens without dose adjustments, indicating the patch’s compatibility with other pain management therapies.
-
Safety and Tolerability
- No serious adverse effects (AEs) or drug interactions were reported, supporting its use in combination therapies.
- The patch was well tolerated even in patients with moderate-to-severe chronic pain.
-
Outcome Measurement
- Pain reduction was assessed using tools like the Neuropathic Pain Scale (NPS), evaluating qualities such as intensity and burning sensations.
Practical Considerations for Purchasers
- Patch Coverage: Ensure sufficient quantity (up to 4 patches/day) for large pain areas.
- Compatibility: Suitable for patients on multi-drug regimens, with no need for dose adjustments.
- Condition-Specific Protocols: Frequency may vary (e.g., PHN might require twice-daily application).
This structured approach highlights the patch’s flexibility in clinical settings while emphasizing its safety and efficacy in diverse pain conditions.
Summary Table:
| Aspect | Details |
|---|---|
| Application Site | Area of maximal pain (e.g., knee, intact skin for PHN, chronic pain regions) |
| Frequency | 1–4 patches/day (max 560 cm²); some studies used twice daily for 2 days |
| Study Design | Open-label, non-randomized, prospective; 2-week duration with 24-hour changes |
| Concurrent Analgesics | No dose adjustments needed; compatible with existing regimens |
| Safety | No serious adverse effects; well-tolerated in moderate-to-severe pain |
| Outcome Measurement | Neuropathic Pain Scale (NPS) for pain intensity, burning sensations, etc. |
Optimize your pain management protocols with Enokon’s reliable transdermal solutions!
As a bulk manufacturer of high-quality lidocaine patches and pain plasters, Enokon partners with healthcare distributors and pharma brands to deliver customizable, clinically validated solutions. Our patches are designed for seamless integration into existing analgesic regimens, ensuring patient safety and efficacy.
Why choose Enokon?
- Technical Expertise: Tailored R&D support for condition-specific formulations.
- Scalable Production: Bulk supply with consistent quality for large-scale needs.
- Regulatory Compliance: Adherence to global standards for pain relief products.
Contact our team today to discuss your requirements or request samples!
