The estradiol transdermal spray is a hormone replacement therapy used to manage menopausal symptoms, vulvar/vaginal atrophy, hypoestrogenism, and osteoporosis prevention. Proper application involves priming the applicator, spraying on the inner forearm, allowing drying time, and avoiding contact with others. Safety precautions include flammability warnings due to alcohol content and dosage limits per applicator.
Key Points Explained:
1. Application Site and Preparation
- Apply to clean, dry skin on the inner forearm (between elbow and wrist).
- Prime the applicator with 3 pumps when new to ensure proper dosage delivery.
- Avoid areas like breasts or vagina, similar to precautions for a transdermal hormone patch.
2. Drying and Post-Application Care
- Wait 2 minutes before dressing to prevent transfer.
- Avoid washing the area for 1 hour post-application to ensure absorption.
- Flammability warning: Contains alcohol; avoid open flames/smoking during/after use.
3. Safety Measures
- Avoid contact with children/pets to prevent accidental exposure.
- Limit sprays per applicator: Do not exceed 56 sprays (ensures accurate dosing).
4. Additional Considerations
- Sunscreen timing: Apply sunscreen 1 hour before the spray to avoid interactions.
- Storage: Keep away from heat/flames due to alcohol content.
5. Indications
- Treats menopausal symptoms (e.g., hot flashes), vulvar/vaginal atrophy, and osteoporosis prevention, aligning with broader hormone therapy goals.
By following these steps, users can optimize efficacy while minimizing risks like skin irritation or accidental exposure. Always consult a healthcare provider for personalized guidance.
Summary Table:
| Key Step | Instructions |
|---|---|
| Application Site | Inner forearm (clean, dry skin). Avoid breasts/vagina. |
| Priming | 3 pumps for new applicator. |
| Drying Time | Wait 2 minutes before dressing; avoid washing for 1 hour. |
| Flammability Warning | Contains alcohol—keep away from flames/smoking. |
| Safety Precautions | Avoid contact with children/pets. Limit to 56 sprays per applicator. |
| Sunscreen Timing | Apply sunscreen 1 hour before spray. |
| Storage | Keep away from heat/open flames. |
| Indications | Menopausal symptoms, vulvar/vaginal atrophy, osteoporosis prevention. |
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