The primary reason for using laboratory-grade hydraulic presses is the preservation of molecular integrity through temperature control. Unlike distillation methods that utilize heat, these pressing devices facilitate a cold-pressing process to extract fixed oils. This technique protects the delicate molecular structure of long-chain unsaturated fatty acids, such as EPA and DHA, ensuring they remain chemically active for transdermal applications.
Core Takeaway: The efficacy of a transdermal system relies on the structural quality of its enhancers. Hydraulic pressing avoids thermal degradation, ensuring fatty acids remain in their free form to effectively disrupt the skin barrier and facilitate drug delivery.
Preserving Chemical Integrity
The Superiority of Cold-Pressing
Laboratory-grade pressing equipment allows for the extraction of oils without the application of external heat.
This stands in direct contrast to distillation, a common separation method that relies on boiling points.
By eliminating high temperatures, the cold-pressing method prevents the breakdown or alteration of sensitive compounds found in raw materials like plant seeds or algal sources.
Protecting Long-Chain Fatty Acids
The specific targets of this process are long-chain unsaturated fatty acids, notably EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid).
These molecules are chemically complex and highly susceptible to degradation when exposed to thermal stress.
Using a hydraulic press ensures that the molecular structure of these critical acids remains intact throughout the extraction process.
Enhancing Transdermal Delivery
Functionality as Permeation Enhancers
For fatty acids to function as effective permeation enhancers, they must be chemically stable.
The preserved EPA and DHA molecules interact directly with the skin to facilitate the transport of therapeutic agents.
Disruption of the Stratum Corneum
The mechanism of action relies on the ability of these fatty acids to disrupt the lipid arrangement of the skin's outermost layer, the stratum corneum.
When the molecular structure is preserved via cold-pressing, these acids can effectively penetrate this barrier.
This disruption creates pathways for the drug payload to pass through the skin more efficiently.
The Necessity of the Free Form
To achieve this lipid disruption, the fatty acids must exist in their free form.
Thermal processing methods like distillation can alter this state, rendering the acids less effective.
Cold-pressing guarantees that the fatty acids retain the specific free-form configuration required to act as potent enhancers.
Understanding the Trade-offs
Process Speed vs. Product Quality
While distillation can be a faster method for separating compounds, it comes at the cost of molecular degradation.
Hydraulic pressing prioritizes the biological activity of the extract over the speed of processing.
Equipment Requirements
Using laboratory-grade hydraulic presses requires specific equipment capable of exerting immense pressure without generating friction heat.
This adds a layer of operational complexity compared to simple thermal separation techniques.
Making the Right Choice for Your Formulation
If you are developing advanced transdermal systems, the extraction method is not merely a manufacturing detail—it is a determinant of clinical efficacy.
- If your primary focus is maximizing permeation enhancement: Prioritize cold-pressing to ensure EPA and DHA remain in their free form to disrupt the stratum corneum.
- If your primary focus is ingredient stability: Avoid distillation to prevent thermal damage to the molecular structure of long-chain unsaturated fatty acids.
By selecting the correct extraction method, you ensure the bio-functional integrity of the critical enhancers in your delivery system.
Summary Table:
| Feature | Cold-Pressing (Hydraulic) | Distillation |
|---|---|---|
| Temperature | Low (Ambient) | High (Boiling Point) |
| Molecular Integrity | Fully Preserved | Risk of Thermal Degradation |
| Fatty Acid State | Active Free Form | Potentially Altered |
| Skin Permeation | High (Effective Enhancer) | Reduced Effectiveness |
| Process Priority | Biological Activity | Processing Speed |
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As a trusted brand and manufacturer, Enokon specializes in wholesale transdermal patches and custom R&D solutions. We understand that the integrity of permeation enhancers like EPA and DHA is vital for clinical efficacy.
Our expertise covers a comprehensive range of drug delivery products—including Lidocaine, Menthol, Capsicum, Herbal, and Far Infrared pain relief, as well as specialized Eye Protection, Detox, and Medical Cooling Gel patches. Whether you need high-potency ingredients or ready-to-market wholesale solutions (excluding microneedle technology), we provide the technical precision your brand deserves.
Ready to optimize your transdermal delivery system? Contact us today to discuss our custom R&D and manufacturing capabilities.
References
- Lizelle T. Fox, Josias H. Hamman. Transdermal Drug Delivery Enhancement by Compounds of Natural Origin. DOI: 10.3390/molecules161210507
This article is also based on technical information from Enokon Knowledge Base .
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