Patients generally rated the acceptability of the ketoprofen patches very highly, with over 80% reporting good or excellent ratings for patch removal and skin adherence. The patch format was preferred not only for its efficacy in pain relief but also for its tolerability and ease of use, requiring just one daily application. Adverse events were primarily cutaneous and occurred at similar rates in both the ketoprofen and placebo groups, indicating they were related to the patch itself rather than the active ingredient. Gastrointestinal adverse events were minimal (<8%) and comparable between groups. Overall, the ketoprofen patch demonstrated excellent compliance and high patient satisfaction in terms of comfort, application, and dosage.
Key Points Explained:
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High Patient Acceptability
- Over 80% of patients rated patch removal and skin adherence as "good" or "excellent," indicating strong patient satisfaction with the ketoprofen patch.
- The patch format was preferred for its tolerability and acceptability, alongside its efficacy in pain relief.
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Ease of Use and Compliance
- The patch required only one daily application, simplifying the treatment regimen and improving patient compliance.
- After 7 days of treatment, patients reported excellent adherence and minimal inconvenience.
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Tolerability and Safety
- Adverse events were primarily cutaneous (e.g., skin irritation) and occurred at similar rates in both the ketoprofen and placebo groups, suggesting they were related to the patch material rather than the drug.
- Gastrointestinal side effects were rare (<8%) and did not differ significantly between the treatment and placebo groups.
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Patient Comfort and Preference
- Patients rated the pharmaceutical shape, application, and dosage comfort significantly higher for the ketoprofen patch compared to alternatives.
- The patch’s design contributed to its high acceptability, making it a favorable option for long-term pain management.
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Clinical Implications
- The high acceptability and tolerability of the ketoprofen patch support its use as a patient-friendly alternative to oral medications, particularly for those prone to gastrointestinal issues.
- Its ease of use and strong compliance rates make it suitable for chronic pain management, where adherence is often a challenge.
The ketoprofen patch stands out as a well-tolerated, convenient, and effective option, aligning with patient needs for comfort and simplicity in pain management therapies.
Summary Table:
| Key Aspect | Patient Feedback |
|---|---|
| Acceptability | >80% rated patch removal & skin adherence as "good" or "excellent." |
| Ease of Use | Preferred for 1x daily application, improving compliance. |
| Tolerability | Cutaneous reactions were patch-related (not drug); GI events rare (<8%). |
| Comfort & Preference | High scores for pharmaceutical shape, dosage comfort, and long-term usability. |
| Clinical Benefit | Ideal for patients with GI sensitivities or adherence challenges. |
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