The Granisetron Transdermal Patch is applied to the upper outer arm on clean, dry, hairless skin free from lotions or irritations. It should be placed 24-48 hours before chemotherapy and remain for at least 24 hours post-treatment, adhering for up to 7 days. Application involves removing protective films stepwise and pressing firmly, with handwashing afterward. If edges lift, medical tape can secure them. Proper rotation of application sites is crucial to avoid skin irritation.
Key Points Explained:
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Preparation of Application Site
- The skin must be clean, dry, and hair-free (avoid shaving immediately before).
- Avoid areas with lotions, oils, redness, or broken skin to ensure proper adhesion and drug absorption.
- Preferred location: upper outer arm (less friction and minimal movement).
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Step-by-Step Application
- Remove from pouch: Do not cut or alter the patch.
- Peel liner: Bend to remove one half of the plastic film, apply the exposed adhesive, then remove the second film and press firmly for 10 seconds.
- Hand hygiene: Wash hands immediately after to prevent accidental drug transfer.
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Timing and Duration
- Pre-treatment: Apply 24–48 hours before chemotherapy to establish therapeutic drug levels.
- Post-treatment: Keep for ≥24 hours after the last dose (total wear time up to 7 days).
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Maintenance and Troubleshooting
- Peeling edges: Secure with medical tape; avoid covering the entire patch to maintain drug release.
- Replacement: If replacing, rotate to a new site (wait ≥1 week before reusing the same area).
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Safety and Disposal
- Avoid exposure: Fold used patches sticky-side in before disposal to prevent accidental contact.
- Skin care: Monitor for irritation; if severe, consult a healthcare provider.
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Mechanism of Action
- The patch delivers granisetron steadily through the skin, bypassing the digestive system for consistent nausea control during chemotherapy.
By following these steps, patients can optimize the patch’s efficacy while minimizing skin irritation or adhesion issues. Always consult a healthcare provider for personalized guidance.
Summary Table:
| Key Aspect | Guidance |
|---|---|
| Application Site | Clean, dry, hair-free upper outer arm; avoid lotions/irritated skin. |
| Application Steps | 1. Remove from pouch. 2. Peel liner in halves. 3. Press firmly for 10 sec. |
| Timing | Apply 24–48 hrs pre-chemo; keep ≥24 hrs post-treatment (up to 7 days total). |
| Maintenance | Secure peeling edges with tape; rotate sites to avoid irritation. |
| Disposal | Fold sticky-side in before disposal to prevent accidental exposure. |
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