The selegiline transdermal patch is a prescribed treatment for major depressive disorder in adults, functioning as a monoamine oxidase inhibitor (MAOI) that delivers sustained medication levels through skin absorption. Applied once daily, it requires careful adherence to placement, rotation, and timing protocols to ensure efficacy and minimize skin irritation. Proper application involves clean, dry skin on approved body areas, firm adhesion, and strict 24-hour replacement cycles while avoiding concurrent use with certain foods or medications due to MAOI interactions.
Key Points Explained:
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Purpose and Mechanism
- The Selegiline Transdermal Patch treats major depressive disorder by inhibiting monoamine oxidase, increasing neurotransmitters like serotonin and dopamine.
- Unlike oral MAOIs, transdermal delivery bypasses gut metabolism, reducing dietary restrictions (e.g., tyramine-rich foods) at lower doses.
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Application Protocol
- Site Selection: Apply to hairless, intact skin on the upper chest, back, outer arm, or upper thigh. Avoid breasts, waistbands, or irritated areas.
- Rotation: Wait ≥1 week before reusing the same site to prevent skin reactions.
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Steps:
- Wash hands and clean the application area with soap/water; pat dry.
- Remove patch from pouch, peel off liner, and press adhesive side firmly for 10–30 seconds.
- Replace every 24 hours at the same time (e.g., mornings).
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Adhesion and Safety
- Ensure edges adhere fully; avoid heat sources (saunas, heating pads) to prevent accelerated drug release.
- Wash hands after handling to avoid accidental eye/mucous membrane exposure.
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Precautions
- Drug Interactions: Contraindicated with other MAOIs, SSRIs, or opioids (risk of serotonin syndrome).
- Skin Care: Monitor for redness/itching; rotate sites to minimize irritation.
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Clinical Considerations
- Higher-dose patches may require dietary tyramine restrictions (≥9 mg/24 hours).
- Patients should report mood changes or unusual behaviors to their prescriber.
By integrating these steps, users optimize therapeutic outcomes while mitigating risks—showcasing how precise patch use bridges pharmacology with daily self-care.
Summary Table:
| Key Aspect | Details |
|---|---|
| Purpose | Treats major depressive disorder by inhibiting monoamine oxidase (MAOI). |
| Application Sites | Upper chest, back, outer arm, or thigh. Avoid breasts and irritated areas. |
| Frequency | Apply once daily, replace every 24 hours at the same time. |
| Precautions | Avoid other MAOIs, SSRIs, opioids, and heat sources. Rotate application sites. |
| Safety Tips | Wash hands after handling; monitor for skin irritation. |
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