The Diclofenac Patch was applied directly to the skin over the painful injury site twice daily for 14 days during the study. If the painful area was smaller than the patch, subjects were allowed to trim it for a better fit. The application process involved cleaning and drying the skin, carefully removing the patch from its packaging, and pressing it firmly onto the targeted area. Each patch contained 1.3% diclofenac epolamine in a hydrophilic adhesive with specific excipients, measuring 10 × 14 cm. This method provided continuous pain relief and was found to be as effective as oral diclofenac, with better compliance and fewer side effects.
Key Points Explained:
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Application Frequency and Duration
- The Diclofenac Patch was applied twice daily for 14 days.
- This consistent application ensured continuous delivery of the medication to the painful area, maintaining therapeutic levels for effective pain relief.
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Placement on the Skin
- The patch was applied directly over the painful injury site, ensuring targeted relief.
- If the painful area was smaller than the patch, subjects could trim it to fit, allowing customization for different injury sizes.
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Patch Composition and Size
- Each patch contained 1.3% diclofenac epolamine (equivalent to 1% diclofenac free acid) in a hydrophilic adhesive with gelatin, polyvinyl pyrrolidone, and other excipients.
- The patch measured 10 × 14 cm, providing a sufficient surface area for drug absorption while remaining manageable for application.
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Preparation and Application Steps
- Skin Preparation: The skin was washed with soap and water and dried completely before application to ensure proper adhesion and absorption.
- Patch Handling: The patch was carefully removed from its packaging, separated from the clear liner, and pressed firmly onto the skin.
- Disposal: Used patches were folded in half to stick to themselves and disposed of properly, with hands washed after handling.
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Effectiveness and Benefits
- The study found the 100 mg transdermal diclofenac patch applied once daily was as effective as 150 mg oral diclofenac for post-extraction analgesia.
- Advantages included better patient compliance (due to ease of use) and fewer adverse effects compared to oral administration.
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Indications for Use
- The patch is designed for short-term pain relief from minor strains, sprains, and bruises in adults and children aged 6 and older.
- As an NSAID, it works by inhibiting the body’s production of pain-causing substances, providing localized relief without systemic side effects.
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Patient Compliance and Safety
- The transdermal method reduces gastrointestinal side effects common with oral NSAIDs.
- Clear instructions (e.g., trimming the patch, proper disposal) enhance usability and safety, making it a practical option for patients.
Have you considered how such patches could simplify pain management in outpatient settings? Their targeted delivery and ease of use make them a quiet yet transformative tool in modern pain relief.
Summary Table:
| Aspect | Details |
|---|---|
| Application Frequency | Twice daily for 14 days |
| Placement | Directly over the painful area; trimmable for smaller injuries |
| Patch Composition | 1.3% diclofenac epolamine in hydrophilic adhesive (10 × 14 cm) |
| Preparation Steps | Clean/dry skin → remove patch → press firmly → dispose folded patch |
| Effectiveness | Comparable to 150 mg oral diclofenac, with better compliance & fewer side effects |
| Indications | Short-term relief for strains, sprains, bruises (ages 6+) |
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