The ketoprofen patch demonstrated superior performance over diclofenac gel in several key areas, particularly in pain relief, functional recovery, and patient comfort. Specifically, it excelled in reducing functional disability by day 7, alleviating pain during passive motion at days 7 and 14, and improving pressure pain by day 7. Additionally, it achieved higher cure rates (64% vs. 46%) for sports-related soft-tissue injuries. Beyond clinical efficacy, patients rated the ketoprofen patches higher in overall treatment comfort, acceptability, and ease of use, with over 80% praising its skin adherence and removal process. These advantages make it a compelling option for acute pain management in sports injuries.
Key Points Explained:
-
Pain Relief and Functional Recovery
- Functional Disability: The ketoprofen patch significantly outperformed diclofenac gel in restoring mobility by day 7.
- Quantitative Pain on Passive Motion: Superior pain reduction was observed at both day 7 and day 14, suggesting longer-lasting efficacy.
- Pain on Pressure: By day 7, the patch provided better relief for localized tenderness, a critical factor in soft-tissue injury recovery.
-
Higher Cure Rates
- The ketoprofen patch achieved a 64% cure rate for injuries, compared to 46% with diclofenac gel, highlighting its clinical effectiveness in resolving acute conditions.
-
Patient-Centric Advantages
- Treatment Comfort: Patients preferred the patch’s pharmaceutical form, application, and once-daily dosing over the gel’s thrice-daily regimen.
- Skin Adherence and Removal: Over 80% rated these aspects as "good" or "excellent," emphasizing user-friendliness.
- Overall Acceptability: Higher scores in tolerance and acceptability assessments suggest better adherence and satisfaction.
-
Comparative Efficacy in Pain Reduction
- While both treatments reduced baseline pain significantly (79% vs. 77%), the ketoprofen patch’s slight edge (-1.17 difference in efficacy scores) and non-inferiority to the gel make it a viable alternative with fewer daily applications.
-
Study Context
- The research focused on acute, sport-related soft-tissue injuries (sprains, strains, contusions) within 48 hours of occurrence, ensuring relevance for athletes and active individuals.
These findings position the ketoprofen patch as a versatile, patient-preferred option for acute pain management, particularly where convenience and sustained relief are priorities.
Summary Table:
| Area of Comparison | Ketoprofen Patch | Diclofenac Gel |
|---|---|---|
| Functional Disability (Day 7) | Significant improvement | Less improvement |
| Pain on Passive Motion (Day 7 & 14) | Superior reduction | Moderate reduction |
| Pain on Pressure (Day 7) | Better relief | Less relief |
| Cure Rate | 64% | 46% |
| Patient Comfort & Adherence | High (80%+ satisfaction) | Lower satisfaction |
Looking for a superior pain management solution? Enokon specializes in high-quality transdermal patches, including ketoprofen patches, designed for optimal pain relief and patient comfort. Our expertise in custom R&D ensures tailored solutions for healthcare and pharma distributors. Contact us today to learn how we can enhance your product line with reliable, patient-preferred pain relief options!
