Diclofenac topical system (patch) is a medicated adhesive patch designed to deliver the NSAID diclofenac through the skin directly to the site of pain. It provides localized relief for acute musculoskeletal pain, such as sprains, strains, and bruises, while minimizing systemic side effects common with oral NSAIDs. The patch format offers convenience with once- or twice-daily application and avoids gastrointestinal irritation associated with oral administration.
Key Points Explained:
-
What is a Diclofenac Patch?
- A transdermal Diclofenac Patch containing diclofenac epolamine (1.3%) or sodium salt
- Classified as a nonsteroidal anti-inflammatory drug (NSAID)
- Designed for topical application to intact skin over painful areas
- Provides controlled release of medication over 12-24 hours
-
Primary Medical Uses
- Treatment of acute pain from minor musculoskeletal injuries:
- Sprains (stretched/torn ligaments)
- Strains (overstretched muscles/tendons)
- Contusions (bruises with tissue injury)
- Off-label uses may include:
- Osteoarthritis joint pain
- Post-surgical incision pain
- Chronic tendinitis
- Treatment of acute pain from minor musculoskeletal injuries:
-
Mechanism of Action
- Inhibits cyclooxygenase (COX) enzymes:
- Reduces prostaglandin production at the injury site
- Decreases inflammation and pain signaling
- Localized effect minimizes systemic absorption:
- Lower risk of GI ulcers vs oral NSAIDs
- Reduced cardiovascular/kidney side effects
- Inhibits cyclooxygenase (COX) enzymes:
-
Application Protocol
- Apply to clean, dry, unbroken skin
- Avoid areas with cuts, rashes, or infections
- Typical dosing:
- 1 patch every 12 hours (epolamine)
- 1 patch daily (sodium formulations)
- Precautions:
- Wash hands after application
- Don't apply heat over patch
- Rotate application sites
-
Advantages Over Other Forms
- Targeted delivery to painful area
- No first-pass liver metabolism
- Lower peak plasma concentrations
- Suitable for patients with:
- Difficulty swallowing pills
- History of NSAID-induced gastritis
- Need for prolonged local therapy
Have you considered how this targeted delivery system might benefit patients with multiple comorbidities who require pain management? The patch format elegantly solves several medication challenges while maintaining therapeutic effectiveness.
Summary Table:
| Feature | Diclofenac Patch Benefits |
|---|---|
| Drug Type | NSAID (diclofenac epolamine/sodium) |
| Primary Use | Acute musculoskeletal pain (sprains, strains, bruises) |
| Key Advantage | Localized relief with minimal systemic absorption |
| Dosing Frequency | Every 12 hours (epolamine) or daily (sodium) |
| Best For | Patients needing targeted therapy or those with oral NSAID intolerances |
Need reliable diclofenac patches for your patients or distribution network?
Enokon specializes in bulk manufacturing of high-quality transdermal pain relief patches, including custom formulations. Our technical expertise ensures:
- Consistent drug delivery performance
- Adhesive systems for optimal wear time
- Compliance with international pharmaceutical standards
Contact our team to discuss partnership opportunities for private labeling or custom R&D projects.
