The primary use of the selegiline transdermal patch is to treat major depressive disorder in adults. As a prescription medication, it belongs to a class of drugs called monoamine oxidase inhibitors (MAOIs), which work by preventing the breakdown of certain chemicals in the brain that are essential for maintaining mental balance.
Selegiline treats depression by increasing the levels of crucial mood-regulating neurotransmitters in the brain. The transdermal patch is designed to deliver a consistent, sustained dose of the medication through the skin over a 24-hour period.
How Selegiline Works to Treat Depression
The Role of Monoamine Oxidase Inhibitors (MAOIs)
Selegiline is a monoamine oxidase inhibitor (MAOI). This class of medication targets and inhibits the action of an enzyme called monoamine oxidase.
This enzyme is responsible for breaking down key neurotransmitters—chemical messengers—in the brain.
Restoring Chemical Balance
In individuals with depression, the levels of these crucial neurotransmitters can be imbalanced.
By blocking the enzyme that clears them out, selegiline helps increase the available supply of these natural substances, which can help restore a more stable mental balance.
Why a Transdermal Patch?
The patch delivery system, known by the brand name Emsam, ensures a steady and sustained release of selegiline into the bloodstream.
This method delivers the medication directly to the brain at consistent levels over a 24-hour period, which can differ from the fluctuating levels associated with some oral medications.
Proper Application and Dosage
Starting and Adjusting Doses
Treatment typically begins with a 6 mg per 24 hours patch applied once daily.
Under a doctor's supervision, the dosage may be increased in 3 mg increments at intervals of two weeks or more, up to a maximum dose of 12 mg per 24 hours.
The 24-Hour Cycle
A new patch must be applied once every 24 hours, typically at the same time each day.
It is critical to remove the old patch before applying the new one. Never wear more than one patch at a time unless specifically directed by your doctor.
Step-by-Step Application
First, wash the chosen area of skin with soap and warm water, then dry it completely. The skin should be smooth and free of irritation.
Apply the patch to the upper chest, back, upper thigh, or the outer surface of the upper arm. Press down firmly for about 30 seconds to ensure it is sealed to the skin.
Rotating Application Sites
To prevent skin irritation, you must rotate the application site each day. Do not apply a new patch to the same exact spot you used the day before.
Common Pitfalls to Avoid
Strict Adherence is Non-Negotiable
The instructions for application are not mere suggestions; they are essential for the medication's safety and effectiveness.
Using more patches, changing them more frequently than prescribed, or applying them incorrectly can lead to improper dosing.
The Importance of Medical Supervision
Selegiline is a powerful medication that requires ongoing medical supervision. All follow-up appointments with your doctor are crucial.
Never adjust your dose or stop the medication without professional guidance.
Full Disclosure of Other Medications
MAOIs can have serious interactions with other substances. It is vital to provide your doctor with a complete, written list of all prescription drugs, over-the-counter medicines, vitamins, and herbal supplements you are taking.
Making the Right Choice for Your Goal
Following your doctor's instructions precisely is the key to using the selegiline patch safely and effectively.
- If your primary focus is starting treatment correctly: Establish a strict daily routine for changing the patch and meticulously follow all application and site rotation instructions.
- If your primary focus is managing your condition: Maintain open communication with your healthcare provider, as dosage adjustments are a normal part of finding the most effective treatment level.
- If your primary focus is safety: Ensure your prescribing doctor and pharmacist have a complete, updated list of every medication and supplement you take to prevent dangerous interactions.
Understanding how your medication works is the first step toward effectively managing your health.
Summary Table:
| Key Aspect | Details |
|---|---|
| Primary Use | Treatment of Major Depressive Disorder (MDD) in adults |
| Drug Class | Monoamine Oxidase Inhibitor (MAOI) |
| Mechanism | Increases levels of mood-regulating neurotransmitters in the brain |
| Standard Dosage | Starts at 6 mg/24 hours, can be increased to a max of 12 mg/24 hours |
| Application | Apply one patch to clean, dry skin (upper chest, back, thigh, arm) every 24 hours |
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