Before any medical or dental procedure, the single most important action is to inform your entire healthcare team—including your surgeon, anesthesiologist, and dentist—that you are using a selegiline patch. This communication is essential because selegiline can have serious, potentially dangerous interactions with medications commonly used during surgery and other procedures.
The core principle is proactive disclosure. Selegiline is a potent medication that can interact with anesthesia and other drugs, and your medical team must be aware of its use to adjust their plan and ensure your safety.

Why Full Disclosure is Critical
Selegiline belongs to a class of drugs known as Monoamine Oxidase Inhibitors (MAOIs). While effective for depression, MAOIs require careful management, especially in a surgical or procedural setting, due to their unique mechanism of action.
The Risk of Drug Interactions
The primary danger lies in how selegiline interacts with other medications. Anesthetics, pain relievers, and other drugs administered during a procedure can trigger severe adverse reactions when combined with an MAOI.
Informing your care team allows them to select alternative medications or adjust dosages to avoid a harmful interaction.
Preventing a Hypertensive Crisis
Certain medications, particularly some anesthetics and vasoconstrictors, can cause a rapid and dangerous spike in blood pressure when they interact with selegiline. This condition, known as a hypertensive crisis, is a medical emergency.
Your anesthesiologist needs to know about your selegiline use to prevent this specific risk.
Preparing for Your Procedure
Beyond simply informing your doctors, there are other considerations to ensure your procedure goes smoothly and safely.
The Possibility of Temporary Removal
Depending on the type of procedure (such as an MRI or CT scan), you may be instructed to remove the patch temporarily. The decision rests entirely with your medical team.
Never remove or alter your medication schedule without explicit instructions from your healthcare provider.
Discuss Your Complete Medical History
Your doctors must be aware of your full health profile. Before starting selegiline, and especially before a procedure, ensure they know if you have a history of bipolar disorder, high blood pressure, or liver disease.
This complete picture helps them make the safest decisions for your care.
Broader Safety Considerations with Selegiline
While preparing for a procedure, it's wise to review the general safety protocols for using the selegiline patch.
Understanding Dietary Restrictions
A key consideration for MAOIs is the interaction with tyramine-rich foods. However, for the selegiline patch, this restriction only applies if your dose is higher than 6 mg per day.
If your dose exceeds 6 mg, you must avoid foods high in tyramine to prevent severe headaches and high blood pressure. This diet must continue for two weeks after stopping the higher dose or reducing it to 6 mg.
Avoid Increasing Body Temperature
External heat can increase the amount of medication your body absorbs from the patch. Avoid hot baths, sunbathing, heating pads, or other heat sources that can raise your body temperature significantly.
Monitor for Changes
Always be vigilant for changes in your mood, worsening depression, or suicidal thoughts. If you feel drowsy or dizzy from the medication, avoid activities that require mental alertness.
How to Ensure a Safe Procedure
Your actions before a medical or dental appointment are crucial. Use these guidelines to prepare effectively.
- If you have any upcoming procedure: Proactively inform every single healthcare provider involved—your surgeon, dentist, anesthesiologist, and primary doctor—that you use a selegiline patch.
- If your dose is above 6 mg/day: Remind your doctor of your dosage, as this has direct implications for both diet and potential drug interactions during your care.
- For all users: Maintain an updated list of all your medications, conditions, and allergies to provide to any medical professional you see for any reason.
Proactive communication with your medical team is the most effective tool you have to guarantee your safety.
Summary Table:
| Key Action Before a Procedure | Why It's Critical |
|---|---|
| Inform all healthcare providers (surgeon, dentist, anesthesiologist) | Selegiline is an MAOI that can cause dangerous interactions with anesthetics and other drugs. |
| Discuss possibility of temporary patch removal | May be required for certain procedures like an MRI; only do so under direct medical instruction. |
| Review dosage & dietary restrictions | Doses above 6 mg/day require a tyramine-free diet to prevent a hypertensive crisis. |
| Provide a full medical history | Helps your care team make the safest decisions for your specific health profile. |
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