If you miss a dose of your selegiline transdermal patch, you should apply a new patch as soon as you remember. However, if it is almost time for your next regularly scheduled application, you should skip the missed dose entirely and simply apply the next patch at its normal time.
The core principle is to get back on your regular 24-hour schedule as smoothly as possible. Never apply two patches at once or use extra patches to compensate for a missed dose, as this significantly increases the risk of side effects.

The Guiding Principle: Restoring Your Schedule Safely
When managing a missed dose, the goal is to maintain a consistent level of medication in your system without creating a dangerous spike.
Immediate Action: Apply as Soon as You Remember
For most of the day, the correct action is simple: as soon as you realize you forgot, remove the old patch (if still on) and apply a new one.
This action helps re-establish the therapeutic level of the medication in your body with minimal disruption.
The Key Exception: When It's "Almost Time"
The only exception to this rule is if you remember very close to your next scheduled application time.
Applying a patch for only a short period before changing it again is inefficient and can disrupt your routine. In this specific case, it is safer to skip the missed dose.
Continuing Your Regular Schedule
After you've addressed the missed dose—either by applying a patch late or skipping it—your next patch should be applied at its normal, originally scheduled time.
Do not shift your entire schedule forward. The objective is always to return to your established routine.
The Critical Rule: Never Double the Dose
The most important instruction in every scenario is to avoid over-medication. Applying more than one patch at a time is dangerous.
Understanding the Risk of Overdose
Selegiline is a potent medication. Using two patches at once can deliver a dangerously high dose to your system.
This can lead to serious adverse effects, including a sudden and severe increase in blood pressure, known as a hypertensive crisis.
Signs of Too Much Medication
Be aware of potential overdose symptoms. If you experience any of the following after misusing the patch, contact poison control or seek emergency medical help immediately:
- Severe headache
- Drowsiness, dizziness, or irritability
- Hallucinations
- Seizures or collapse
- Irregular heartbeat or trouble breathing
Making the Right Choice for Your Goal
Your action depends entirely on when you remember the missed dose. Use this simple guide to make a safe decision.
- If you remember with many hours left before your next application: Apply a new patch as soon as you remember and then apply your next one at the regularly scheduled time.
- If you remember when it's almost time for your next application: Skip the missed dose completely and just apply your next patch as you normally would.
- If you are ever in doubt: Contact your doctor or pharmacist for personalized advice before taking any action.
Ultimately, maintaining your prescribed routine is key to safely and effectively managing your condition.
Summary Table:
| Situation | Action to Take |
|---|---|
| Remembered with many hours before next dose | Apply a new patch immediately. Apply next patch at the normal time. |
| Remembered close to the next scheduled dose | Skip the missed dose. Apply the next patch at the normal time. |
| Critical Rule | Never apply two patches at once to avoid overdose risk. |
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