To apply a new selegiline patch, you must first wash and thoroughly dry a clean, healthy area of skin. After removing the patch from its pouch, you will peel off a protective liner, press the sticky side to your skin, remove the second liner, and press the entire patch firmly for about 30 seconds to ensure it is sealed.
The effectiveness of your treatment depends not just on remembering to change the patch, but on a precise application method. Proper skin preparation, site rotation, and secure adhesion are critical for ensuring a consistent dose and preventing skin irritation.

Preparing the Skin: The Foundation for Success
The condition of your skin directly impacts how well the patch adheres and how effectively the medication is absorbed. Taking a moment to prepare the site is a non-negotiable step.
Choosing the Right Location
Select an application site that is dry, intact, and relatively smooth.
The approved locations for the selegiline patch are the upper chest or back, the outer part of the upper arm, or the upper thigh.
Ensuring a Clean Surface
Before application, wash the chosen area with plain soap and warm water.
Rinse thoroughly and pat the skin completely dry with a clean towel. Do not use lotions, oils, or creams on the area, as they can prevent the patch from sticking properly.
What to Avoid
Never apply the patch to skin that is hairy, oily, irritated, broken, or scarred. Avoid any areas with calluses or skin folds that could prevent the patch from lying flat and making full contact.
The Step-by-Step Application Process
Follow these steps carefully each time you apply a new patch. Always wash your hands before and after the process.
1. Open and Prepare the Patch
Only open the sealed pouch when you are ready to apply the patch. Do not use a patch from a pouch that is damaged or has been opened previously.
2. The Two-Liner System
The patch has a protective liner that is often split into two pieces. Peel off the first piece of the liner, being careful not to touch the sticky adhesive side of the patch.
3. Place and Secure
Immediately press the exposed sticky side of the patch firmly onto your prepared skin.
Next, peel off the second piece of the protective liner and press down on the entire patch with the palm of your hand for about 30 seconds to ensure the edges are securely sealed.
Daily Management and Patch Replacement
Consistency is key to managing your condition. This involves changing the patch on a strict schedule and properly caring for your skin.
Maintain a Consistent Schedule
The selegiline patch should be worn for 24 hours.
Change your patch at the same time each day to maintain a stable level of medication in your system.
The Importance of Site Rotation
When you apply a new patch, always choose a different location from the one you used the day before. Rotating sites is crucial for preventing skin irritation and redness.
Safe Disposal
After 24 hours, carefully peel off the old patch. Fold it in half with the sticky sides together and dispose of it in a trash can out of the reach of children and pets.
Common Pitfalls and How to Address Them
Even with careful application, issues can arise. Knowing how to handle them ensures your treatment remains uninterrupted.
If the Patch Loosens or Falls Off
You can bathe, shower, or swim while wearing the patch, but water may sometimes loosen the edges. If an edge lifts, you can press it back down or secure it with medical tape.
If the patch falls off completely, apply a new patch to a different site for the remainder of the day. The next day, change the patch at your regular, scheduled time. Do not apply more patches than prescribed.
Avoiding Heat and Sunlight
Do not expose the patch to direct heat sources. This includes heating pads, electric blankets, saunas, hot tubs, or prolonged, direct sunlight. Excess heat can cause a rapid release of medication, leading to a dangerous overdose.
Making the Right Choice for Your Goal
- If your primary focus is consistent medication delivery: Ensure you press the patch firmly for a full 30 seconds and check that the edges are sealed, especially after showering.
- If your primary focus is preventing skin irritation: Make daily site rotation your top priority and never apply a new patch to the same spot two days in a row.
- If your primary focus is safety: Always avoid external heat sources on the patch and dispose of used patches immediately by folding them sticky-side in.
Following this precise routine for applying and managing your selegiline patch ensures you receive the intended therapeutic benefit safely and effectively.
Summary Table:
| Step | Key Action | Important Consideration |
|---|---|---|
| 1. Preparation | Wash & dry skin with soap/water. | Avoid lotions, oils, or broken/irritated skin. |
| 2. Location | Apply to upper chest, back, arm, or thigh. | Rotate site daily to prevent skin irritation. |
| 3. Application | Remove liners, press patch firmly for 30 sec. | Ensure edges are sealed to the skin. |
| 4. Management | Change patch after 24 hours at the same time daily. | Fold used patch in half (sticky sides together) before disposal. |
| 5. Safety | Avoid direct heat sources (e.g., heating pads, saunas). | If patch falls off, apply a new one to a different site. |
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