Which medications interact with diclofenac skin patch? Avoid These Risky Drug Combinations

Diclofenac skin patches are commonly used for localized pain relief, but they can interact with several medications, potentially leading to adverse effects or reduced efficacy. Key interactions include avoidance with cidofovir, ketorolac, and methotrexate due to heightened risks of kidney toxicity or bleeding. Other significant interactions involve alcohol, blood thinners, diuretics, and certain blood pressure medications. Always consult a healthcare provider before combining diclofenac patches with other drugs to ensure safety and effectiveness.

Key Points Explained:

1. Absolute Contraindications (Avoid Combining)

   • Cidofovir: Increased risk of kidney damage when combined with diclofenac.
   • Ketorolac: Concurrent use with other NSAIDs like diclofenac raises bleeding risks and gastrointestinal ulcers.
   • Methotrexate: Diclofenac can reduce methotrexate clearance, leading to toxicity (e.g., bone marrow suppression).

2. High-Risk Interactions

   • Blood Thinners (e.g., Warfarin, Aspirin): Diclofenac may amplify bleeding risks by inhibiting platelet function.
   • Diuretics (e.g., Furosemide): NSAIDs like diclofenac can reduce diuretic effectiveness and worsen kidney function.
   • Lithium: Diclofenac may increase lithium levels in the blood, risking toxicity (tremors, confusion).

3. Moderate-Risk Interactions

   • Blood Pressure Medications (e.g., ACE Inhibitors, Beta-Blockers): Diclofenac may diminish their antihypertensive effects.
   • Osteoporosis Drugs (e.g., Bisphosphonates): Potential for increased gastrointestinal irritation.
   • Pemetrexed: NSAIDs can delay pemetrexed excretion, raising toxicity risks.

4. Other Notable Interactions

   • Alcohol: May exacerbate gastrointestinal side effects (e.g., stomach bleeding).
   • Steroids (e.g., Prednisone): Combined use heightens ulcer risks.
   • Other NSAIDs: Additive side effects without additional pain relief benefits.

5. General Precautions

   • Always disclose all medications (prescription, OTC, supplements) to your healthcare provider before using diclofenac patches.
   • Monitor for signs of interaction (e.g., unusual bleeding, swelling, dizziness) and seek medical advice if they occur.

For personalized guidance, consult a pharmacist or doctor to evaluate your specific medication regimen.

Summary Table:

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