The ketoprofen patch is generally considered a safe and effective option for treating localized pain and inflammation, with most studies highlighting its good tolerability and low systemic adverse effects. However, some cases of local allergic reactions have been reported, which were not observed with diclofenac patches. Gastrointestinal adverse events were minimal (less than 8%) and comparable to placebo. Overall, the patch format is well-accepted by patients due to its efficacy, convenience, and favorable safety profile.
Key Points Explained:
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Local Allergic Reactions
- A few cases of local allergic reactions were noted with the ketoprofen patches, which were not reported with diclofenac patches.
- These reactions were likely due to skin sensitivity to the adhesive or active ingredient, though they were not widespread.
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Low Incidence of Gastrointestinal Adverse Events
- Systemic side effects, particularly gastrointestinal issues, were rare (less than 8% of patients) and occurred at similar rates in both ketoprofen and placebo groups.
- This suggests that the transdermal delivery method minimizes systemic absorption, reducing the risk of stomach-related complications commonly seen with oral NSAIDs.
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Overall Safety and Tolerability
- The patch demonstrated excellent pain relief and tolerability with just one daily application, leading to high patient compliance.
- Secondary outcomes, such as reduced swelling, improved mobility, and better sleep quality, further support its clinical utility.
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Patient Preference and Convenience
- Patients favored the patch format over gels or oral medications due to its ease of use, sustained effect, and minimal side effects.
- The single daily application enhances adherence, making it a practical choice for long-term pain management.
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Comparative Efficacy with Diclofenac Gel
- The ketoprofen patch showed comparable efficacy to diclofenac gel in reducing pain at rest and during activity, with the added benefit of fewer local skin reactions.
While adverse reactions are rare, healthcare providers should monitor for localized skin sensitivity when prescribing ketoprofen patches. The overall risk-benefit profile remains favorable for most patients.
Summary Table:
| Key Aspect | Details |
|---|---|
| Local Allergic Reactions | Rare cases reported, likely due to skin sensitivity to adhesive/ingredient. |
| Gastrointestinal Effects | Minimal (less than 8%), comparable to placebo. |
| Overall Tolerability | High patient compliance, single daily application, sustained pain relief. |
| Patient Preference | Preferred over gels/oral meds for convenience and fewer side effects. |
| Comparative Efficacy | Matches diclofenac gel efficacy with fewer skin reactions. |
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