What Is The Composition Of The Clonidine Transdermal Therapeutic System?

The clonidine transdermal therapeutic system is a multi-layered patch designed for controlled drug delivery through the skin. Its composition includes distinct functional layers that work together to ensure consistent medication release while maintaining adhesion and protection. The system's design allows for bypassing first-pass metabolism, providing steady therapeutic effects with lower doses compared to oral administration.

Key Points Explained:

Backing Layer
- Made of pigmented polyester and aluminum film
- Provides structural support and environmental protection
- Acts as the outermost visible layer of the Clonidine Transdermal Patch
Drug Reservoir
- Contains the active pharmaceutical ingredient clonidine
- Includes excipients: mineral oil (vehicle), polyisobutylene (adhesive polymer), and colloidal silicon dioxide (viscosity modifier)
- Maintains at least 40% saturation to ensure continuous delivery
- Stores sufficient drug quantity for sustained release (typically 7-day wear time)
Rate-Controlling Membrane
- Microporous polypropylene layer
- Determines the speed of drug diffusion into the skin
- Creates a consistent release profile (typically 0.1-0.3 mg/day for clonidine)
- Prevents dose dumping while allowing therapeutic delivery
Adhesive Layer
- Contains similar composition to the drug reservoir (clonidine + excipients)
- Ensures firm attachment to the skin surface
- May contribute to initial drug loading dose
Release Liner
- Protective polyester layer removed before application
- Preserves adhesive properties during storage
- Typically marked with dosage information

Have you considered how the mineral oil in the reservoir affects drug solubility and skin permeability? This vehicle choice significantly influences the patch's pharmacokinetic profile.

The system's layered architecture demonstrates how transdermal technology balances drug stability, controlled release, and patient comfort—factors crucial for chronic conditions requiring long-term medication. These discreet patches exemplify how material science innovations create medical devices that improve treatment adherence while minimizing systemic side effects.

Summary Table:

Layer	Composition	Function
Backing Layer	Pigmented polyester + aluminum film	Structural support, environmental protection
Drug Reservoir	Clonidine + mineral oil (vehicle), polyisobutylene (adhesive), colloidal SiO₂	Stores and releases active ingredient (≥40% saturation for 7-day wear)
Rate-Controlling Membrane	Microporous polypropylene	Controls diffusion speed (0.1–0.3 mg/day)
Adhesive Layer	Clonidine + excipients (similar to reservoir)	Ensures skin adhesion; may contribute to initial dose
Release Liner	Polyester	Protects adhesive during storage; marked with dosage info

Need custom transdermal patches for your healthcare brand? Partner with Enokon—a bulk manufacturer of reliable transdermal therapeutic systems. Our expertise in multi-layer drug delivery ensures:

Precise dosing with optimized excipient blends (e.g., mineral oil for solubility)
Extended wear (7+ days) through advanced adhesive polymers
Custom R&D for tailored release profiles (e.g., rate-controlling membranes)

Related Products

Far Infrared Heat Pain Relief Patches Transdermal Patches

A pain reliever patch containing herbal extract that quickly heats up and relieves pain. Used for various pain conditions caused by joint and muscle pain, shoulder and back pain, fracture pain, frostbite, and sprains, especially suitable for pain caused by various injuries and chronic pain.

Far Infrared Deep Heat Relief Patches Medicated Pain Relief Patches

Far infrared pain relief patch is a new type of pain relief patch for neck pain use, its main principle is to use far infrared to penetrate into the human body to achieve the effect of pain relief,Far infrared rays can relieve pain. After penetrating the human body, far infrared rays will accelerate blood circulation and promote metabolism, thereby eliminating local pain. In addition, far infrared rays can also improve immunity and antioxidant capacity, which has the effect of improving overall health. This product is suitable for pain caused by various soft tissue injuries and sports injuries, such as cervical spondylosis, shoulder periarthritis, lumbar disc herniation, rheumatoid arthritis, etc

Heating Pain Relief Patches for Menstrual Cramps

Heating Pain Relief Patches for menstrual cramps – natural, self-heating therapy with herbal extracts. Soothes pain for 8-12 hours, discreet & drug-free. Try now!

Herbal Eye Protection Patch Eye Patch

This eye protection patch is rich in Chinese herbal essence, according to the principle of traditional Chinese medicine sticking penetration points, Chinese herbs are carefully proportionally refined. Users include children, teenagers to prevent myopia, office workers, etc.; Single-piece packaging is convenient to carry, when the eyes feel uncomfortable, wear an eye mask or eye mask over the eyes, cool and comfortable immediately relieve eye discomfort; It can be used anywhere, on the subway, on the plane, at the office, at school, at home and so on.

Capsaicin Chili Medicated Pain Relief Patches

Relieve joint and muscle pain. Capsicum Plaster is a plaster applied to aching joints and muscles, aching shoulders and lumbago, broken bones, arthritis, and sprains. It is suitable for all kinds of pain caused by joint muscle pain, sore shoulder and back pain, arthritis and sprain. It is especially suitable for pain and chronic pain caused by various injuries. middle size with 8*13cm.

Asthma Cough and Pain Relief Patch for Adults and Kids

Cough relief patch adopts advanced and important extraction technology to extract the effective ingredients, and is prepared according to the scientific ratio of ancient Chinese prescriptions. It can be applied to the body acupoints, which can clear the lung and reduce phlegm, relieve cough and relieve asthma. It is suitable for adults and children.

Menthol Gel Pain Relief Patch

The main effects of pain relief patch include: • Pain relief: For local pain caused by a variety of causes, such as neuropathic pain, musculoskeletal pain, joint pain and postherpetic neuralgia, pain relief gel patch can effectively reduce the level of pain. It can block the transmission of pain signals to achieve analgesic effect. • Easy to use: Compared to oral painkillers, pain relief gel cold compress patches are easier to use. Simply by applying the patch to the skin at the painful site, the drug can be gradually released to continue its analgesic effect, while reducing the side effects such as gastrointestinal discomfort that may be caused by oral medication. • Promote healing: Some ingredients in pain relief patches can promote fibroblast proliferation and migration, speed up the wound healing process, and promote wound healing after mild trauma. Please note that the use should follow the doctor's advice, pay attention to the skin reaction, in case of discomfort, should immediately stop and seek medical attention.size 7*10cm

Icy Hot Menthol Medicine Pain Relief Patch

The main effects of pain relief gel patch include: • Pain relief: For local pain caused by a variety of causes, such as neuropathic pain, musculoskeletal pain, joint pain and postherpetic neuralgia,pain relief patch can effectively reduce the level of pain. It can block the transmission of pain signals to achieve analgesic effect. • Easy to use: Compared to oral painkillers, painkillers are easier to use. Simply by applying the patch to the skin at the painful site, the drug can be gradually released to continue its analgesic effect, while reducing the side effects such as gastrointestinal discomfort that may be caused by oral medication. • Promote healing: Some ingredients in pain relief patches can promote fibroblast proliferation and migration, speed up the wound healing process, and promote wound healing after mild trauma. Please note that the use should follow the doctor's advice, pay attention to the skin reaction, in case of discomfort, should immediately stop and seek medical attention.

Mugwort Wormwood Pain Relief Patch for Neck Pain

Mugwort Wormwood Pain Relief Patch: Natural herbal solution for neck, joint & muscle pain. Non-invasive, long-lasting relief with anti-inflammatory botanicals. Ideal for athletes & chronic pain sufferers.

Far Infrared Pain Patch Relief Pain Reliever for Back

Relieve Back pain /backache and muscle pain. Far infrared pain relief patch is a new type of pain relief patch, its main principle is to use far infrared to penetrate into the human body to achieve the effect of pain relief,Far infrared rays can relieve pain. After penetrating the human body, far infrared rays will accelerate blood circulation and promote metabolism, thereby eliminating local pain. In addition, far infrared rays can also improve immunity and antioxidant capacity, which has the effect of improving overall health. This product is suitable for pain caused by various soft tissue injuries and sports injuries, such as cervical spondylosis, shoulder periarthritis, lumbar disc herniation, rheumatoid arthritis, etc

Prostate Pain Kidney Health Care Patch for Men

This product adopts advanced Chinese medicine extraction technology, concentrates herbal essence, regulates male endocrine, promotes metabolism, and has a good effect on relieving male prostatitis, premature ejaculation, impotence, frequent urination, dysuria and other symptoms. Replaced every 12-24 hours

Lidocaine Hydrogel Pain Relief Patch for Pain Relief

4% Lidocaine hydrogel pain relief patch for targeted neuropathic & joint pain management. Clinically proven 68% pain reduction with 8-hour sustained release. Hypoallergenic & water-resistant.

Heat Relief Capsicum Patch for Lower Back Pain Relief

Hydra Gel Health Care Eye Patch

The eye production patch is designed with hydrogel. According to the principle of acupoint infiltration of eyes, use well-prepared Chinese herbal medicine. The users include children, teenagers to prevent myopia, office worker and so on; The single piece packing is convenient to carry, put an eye patch or eye mask on you eye when the eye feels uncomfortable, cool and comfortable immediately alleviate the eye discomfort; It can be used anywhere, on the subway, on the plane, in the office, at school and at home, etc.

Natural Herbal Wormwood Patch Pain Plaster

Natural Herbal Wormwood Patch for pain relief - targets arthritis, muscle aches, and joint stiffness. Breathable, long-lasting, and suitable for all ages. Order now for fast relief!

Menu

What is the composition of the clonidine transdermal therapeutic system? | Layer-by-Layer Breakdown

Key Points Explained:

Summary Table:

Related Products

Leave Your Message