The ketoprofen and diclofenac patches were applied in two distinct clinical scenarios. In the first, a randomized study of sport-related soft-tissue injuries, the ketoprofen patches (100 mg once daily) were applied to the injury site for 7-14 days, showing superior efficacy over diclofenac gel. In the second scenario involving dental extractions, a ketoprofen patch was initially applied following premolar extractions in the 1st and 4th quadrants, while a diclofenac patch was later applied to the deltoid region after subsequent extractions in the 2nd and 3rd quadrants.
Key Points Explained:
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Sport-Related Injury Application:
- Location: Applied directly to the site of soft-tissue injuries (sprains, strains, contusions)
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Timing:
- Treatment began within 48 hours of injury
- Continued for 7-14 days based on study duration
- Frequency: Single daily application (100 mg ketoprofen patch)
- Comparative Context: Outperformed diclofenac gel (applied 3 times daily) in multiple efficacy measures
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Dental Extraction Application:
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Initial Phase:
- Location: Applied following premolar extractions in 1st and 4th quadrants
- Timing: Immediately post-extraction
- Duration: Remained for one week
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Secondary Phase:
- Location: Diclofenac patch applied to right deltoid region
- Timing: After second round of extractions (2nd and 3rd quadrants)
- Context: Demonstrates alternative administration sites beyond injury locations
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Initial Phase:
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Clinical Performance Insights:
- The transdermal delivery system showed particular advantages in:
- Functional disability improvement
- Pain reduction during motion and pressure
- Higher cure rates (64% vs 46%)
- Patient comfort and acceptability
- The transdermal delivery system showed particular advantages in:
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Administration Considerations:
- Patch application frequency varied by formulation (daily vs multi-daily alternatives)
- Site selection depended on both injury location and alternative absorption sites
- Duration typically aligned with acute injury timelines (1-2 weeks)
These applications highlight the versatility of transdermal NSAID delivery, with optimal placement depending on both the condition being treated and the specific pharmacokinetic properties of each formulation. The dental case particularly illustrates how clinicians might rotate application sites during sequential procedures.
Summary Table:
| Application Scenario | Patch Type | Location | Timing/Duration | Key Findings |
|---|---|---|---|---|
| Sport-Related Injuries | Ketoprofen (100 mg) | Directly on injury site | 7-14 days (single daily application) | Superior to diclofenac gel in pain reduction, functional improvement, and cure rates (64% vs 46%) |
| Dental Extractions | Ketoprofen → Diclofenac | 1st/4th quadrants → Deltoid region | Immediate post-extraction (1 week) | Demonstrated versatility in site rotation for sequential procedures |
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