Knowledge How should the estradiol and levonorgestrel combination skin patch be applied? A Step-by-Step Guide for Safe Use
Author avatar

Tech Team · Enokon

Updated 3 weeks ago

How should the estradiol and levonorgestrel combination skin patch be applied? A Step-by-Step Guide for Safe Use


To apply the estradiol and levonorgestrel patch, you must place it on a clean, dry, and hair-free area of your lower stomach or upper buttock. Ensure the skin is free of any powder, oil, or lotion. After peeling off the protective backing, press the patch firmly onto the skin for about 10 seconds to make sure it is sealed correctly.

The core principle of applying this patch is ensuring consistent and safe hormone delivery. This involves not only the physical application technique but also a disciplined weekly routine and an understanding of the critical health factors involved with this therapy.

How should the estradiol and levonorgestrel combination skin patch be applied? A Step-by-Step Guide for Safe Use

The Step-by-Step Application Process

Proper application is the foundation for making this medication work as intended. Following a precise method minimizes skin irritation and ensures you receive the correct dose.

Choosing the Right Location

The patch must be applied to the lower stomach (abdomen) or the upper buttocks. These areas provide a good surface for adhesion and consistent absorption.

Avoid applying the patch to your breasts or waistline, where clothing might rub against it and cause it to detach.

Preparing Your Skin

Your skin must be clean, dry, and free of hair. Do not apply any powder, oil, or lotion to the area before application, as this will prevent the patch from sticking properly.

Never apply the patch to skin that is irritated, cut, or has any type of burn or rash.

Applying the Patch

First, carefully peel the protective liner off the patch. Immediately place the sticky side down onto your chosen skin area.

Press down firmly with the palm of your hand for approximately 10 seconds. Run your fingers around the edges to ensure it is sealed completely.

Establishing Your Weekly Routine

This patch is typically applied once per week. It's crucial to change your patch on the same day each week to maintain stable hormone levels.

You must rotate the application site with each new patch. Do not apply a new patch to the exact same spot for at least one week to prevent skin irritation.

Managing Your Dosing Schedule

Consistency is vital for hormone replacement therapy. Knowing how to handle a missed dose prevents disruption to your treatment.

What to Do If You Forget a Patch

If you forget to change your patch on the scheduled day, apply a new one as soon as you remember.

However, if it is almost time for your next scheduled dose, skip the missed one and get back on your regular schedule. Never apply two patches at once to make up for a missed dose.

Critical Safety Considerations and Trade-offs

This medication is effective for treating menopausal symptoms like hot flashes and preventing osteoporosis, but its use involves significant health considerations that require careful medical supervision.

Understanding the Associated Risks

Using this patch can increase the risk of serious health conditions. These include blood clots, stroke, heart attack, dementia, and certain types of cancer, such as breast, endometrial, or uterine cancer. It may also increase the risk of gallbladder disease.

The Importance of Medical Supervision

Regular check-ups with your doctor are essential to monitor for any unwanted effects and to ensure the benefits of the treatment continue to outweigh the risks for you.

Pre-existing Conditions and Lifestyle

Inform your doctor about your complete medical history. Conditions like asthma, diabetes, epilepsy, liver disease, or high blood pressure may be affected by this medication.

It is also critical to avoid smoking, as it significantly increases the risk of serious side effects like blood clots and stroke. Discuss all other medications and supplements you take with your doctor to avoid potential interactions.

Making the Right Choice for Your Goal

  • If your primary focus is correct application: Always use a clean, dry, rotated site on the lower abdomen or upper buttocks and press firmly for 10 seconds.
  • If your primary focus is managing your treatment schedule: Apply a missed patch as soon as you remember, but never double the dose to make up for it.
  • If your primary focus is overall safety: Maintain open and continuous communication with your doctor about all risks, side effects, and any other medications you are taking.

Following these guidelines empowers you to use your medication safely and effectively as part of your overall health plan.

Summary Table:

Key Aspect Crucial Step
Application Site Lower abdomen or upper buttock; rotate weekly.
Skin Preparation Must be clean, dry, hair-free, and free of lotions/oils.
Application Technique Press firmly for 10 seconds; ensure edges are sealed.
Dosing Schedule Apply once weekly on the same day; do not use two patches if a dose is missed.
Safety First Regular doctor check-ups are essential; avoid smoking.

Need a reliable supplier for hormone replacement therapy patches?

As a trusted partner for healthcare distributors and pharmaceutical brands, Enokon specializes in the bulk manufacturing of high-quality, reliable transdermal patches. Our technical expertise ensures consistent drug delivery and superior patient adherence.

We can help you:

  • Develop custom transdermal solutions tailored to your active pharmaceutical ingredients (APIs).
  • Scale production with rigorous quality control for consistent, batch-to-batch reliability.
  • Leverage our R&D expertise to innovate and improve your transdermal product line.

Let's discuss your project. Contact our experts today to explore how our manufacturing capabilities can support your brand's success.

Visual Guide

How should the estradiol and levonorgestrel combination skin patch be applied? A Step-by-Step Guide for Safe Use Visual Guide

Related Products

People Also Ask

Related Products

Capsaicin Chili Medicated Pain Relief Patches

Capsaicin Chili Medicated Pain Relief Patches

Relieve joint and muscle pain. Capsicum Plaster is a plaster applied to aching joints and muscles, aching shoulders and lumbago, broken bones, arthritis, and sprains. It is suitable for all kinds of pain caused by joint muscle pain, sore shoulder and back pain, arthritis and sprain. It is especially suitable for pain and chronic pain caused by various injuries. middle size with 8*13cm.

Far Infrared Deep Heat Relief Patches Medicated Pain Relief Patches

Far Infrared Deep Heat Relief Patches Medicated Pain Relief Patches

Far infrared pain relief patch is a new type of pain relief patch for neck pain use, its main principle is to use far infrared to penetrate into the human body to achieve the effect of pain relief,Far infrared rays can relieve pain. After penetrating the human body, far infrared rays will accelerate blood circulation and promote metabolism, thereby eliminating local pain. In addition, far infrared rays can also improve immunity and antioxidant capacity, which has the effect of improving overall health. This product is suitable for pain caused by various soft tissue injuries and sports injuries, such as cervical spondylosis, shoulder periarthritis, lumbar disc herniation, rheumatoid arthritis, etc

Heating Pain Relief Patches for Menstrual Cramps

Heating Pain Relief Patches for Menstrual Cramps

Heating Pain Relief Patches for menstrual cramps – natural, self-heating therapy with herbal extracts. Soothes pain for 8-12 hours, discreet & drug-free. Try now!

Asthma Cough and Pain Relief Patch for Adults and Kids

Asthma Cough and Pain Relief Patch for Adults and Kids

Cough relief patch adopts advanced and important extraction technology to extract the effective ingredients, and is prepared according to the scientific ratio of ancient Chinese prescriptions. It can be applied to the body acupoints, which can clear the lung and reduce phlegm, relieve cough and relieve asthma. It is suitable for adults and children.

Far Infrared Knee Pain Patch Heat Patches for Pain Relief

Far Infrared Knee Pain Patch Heat Patches for Pain Relief

Relieve Knee joint and muscle pain. Far infrared knee pain relief patch is a new type of pain relief patch, its main principle is to use far infrared to penetrate into the human body to achieve the effect of pain relief,Far infrared rays can relieve pain. After penetrating the human body, far infrared rays will accelerate blood circulation and promote metabolism, thereby eliminating local pain. In addition, far infrared rays can also improve immunity and antioxidant capacity, which has the effect of improving overall health. This product is suitable for pain caused by various soft tissue injuries and sports injuries, such as cervical spondylosis, shoulder periarthritis, lumbar disc herniation, rheumatoid arthritis, etc

Far Infrared Pain Patch Relief Pain Reliever for Back

Far Infrared Pain Patch Relief Pain Reliever for Back

Relieve Back pain /backache and muscle pain. Far infrared pain relief patch is a new type of pain relief patch, its main principle is to use far infrared to penetrate into the human body to achieve the effect of pain relief,Far infrared rays can relieve pain. After penetrating the human body, far infrared rays will accelerate blood circulation and promote metabolism, thereby eliminating local pain. In addition, far infrared rays can also improve immunity and antioxidant capacity, which has the effect of improving overall health. This product is suitable for pain caused by various soft tissue injuries and sports injuries, such as cervical spondylosis, shoulder periarthritis, lumbar disc herniation, rheumatoid arthritis, etc

Medical Cooling Gel Patches for Fever Cooling Patches

Medical Cooling Gel Patches for Fever Cooling Patches

Cooling gel patch for body fever is produced according to hydragel. normal standard type, can choose with blue, pink, or yellow color. And it is a soft gel strip that has been especially designed to relieve discomfort from baby/child/Adult fevers and other minor ailments with a powerful cooling effect that lasts up to 10 hours.

Far Infrared Heat Pain Relief Patches Transdermal Patches

Far Infrared Heat Pain Relief Patches Transdermal Patches

A pain reliever patch containing herbal extract that quickly heats up and relieves pain. Used for various pain conditions caused by joint and muscle pain, shoulder and back pain, fracture pain, frostbite, and sprains, especially suitable for pain caused by various injuries and chronic pain.

Menthol Gel Pain Relief Patch

Menthol Gel Pain Relief Patch

The main effects of pain relief patch include: • Pain relief: For local pain caused by a variety of causes, such as neuropathic pain, musculoskeletal pain, joint pain and postherpetic neuralgia, pain relief gel patch can effectively reduce the level of pain. It can block the transmission of pain signals to achieve analgesic effect. • Easy to use: Compared to oral painkillers, pain relief gel cold compress patches are easier to use. Simply by applying the patch to the skin at the painful site, the drug can be gradually released to continue its analgesic effect, while reducing the side effects such as gastrointestinal discomfort that may be caused by oral medication. • Promote healing: Some ingredients in pain relief patches can promote fibroblast proliferation and migration, speed up the wound healing process, and promote wound healing after mild trauma. Please note that the use should follow the doctor's advice, pay attention to the skin reaction, in case of discomfort, should immediately stop and seek medical attention.size 7*10cm

Icy Hot Menthol Medicine Pain Relief Patch

Icy Hot Menthol Medicine Pain Relief Patch

The main effects of pain relief gel patch include: • Pain relief: For local pain caused by a variety of causes, such as neuropathic pain, musculoskeletal pain, joint pain and postherpetic neuralgia,pain relief patch can effectively reduce the level of pain. It can block the transmission of pain signals to achieve analgesic effect. • Easy to use: Compared to oral painkillers, painkillers are easier to use. Simply by applying the patch to the skin at the painful site, the drug can be gradually released to continue its analgesic effect, while reducing the side effects such as gastrointestinal discomfort that may be caused by oral medication. • Promote healing: Some ingredients in pain relief patches can promote fibroblast proliferation and migration, speed up the wound healing process, and promote wound healing after mild trauma. Please note that the use should follow the doctor's advice, pay attention to the skin reaction, in case of discomfort, should immediately stop and seek medical attention.

Lidocaine Hydrogel Pain Relief Patch for Pain Relief

Lidocaine Hydrogel Pain Relief Patch for Pain Relief

4% Lidocaine hydrogel pain relief patch for targeted neuropathic & joint pain management. Clinically proven 68% pain reduction with 8-hour sustained release. Hypoallergenic & water-resistant.

Prostate Pain Kidney Health Care Patch for Men

Prostate Pain Kidney Health Care Patch for Men

This product adopts advanced Chinese medicine extraction technology, concentrates herbal essence, regulates male endocrine, promotes metabolism, and has a good effect on relieving male prostatitis, premature ejaculation, impotence, frequent urination, dysuria and other symptoms. Replaced every 12-24 hours

Hydra Gel Health Care Eye Patch

Hydra Gel Health Care Eye Patch

The eye production patch is designed with hydrogel. According to the principle of acupoint infiltration of eyes, use well-prepared Chinese herbal medicine. The users include children, teenagers to prevent myopia, office worker and so on; The single piece packing is convenient to carry, put an eye patch or eye mask on you eye when the eye feels uncomfortable, cool and comfortable immediately alleviate the eye discomfort; It can be used anywhere, on the subway, on the plane, in the office, at school and at home, etc.

Herbal Eye Protection Patch Eye Patch

Herbal Eye Protection Patch Eye Patch

This eye protection patch is rich in Chinese herbal essence, according to the principle of traditional Chinese medicine sticking penetration points, Chinese herbs are carefully proportionally refined. Users include children, teenagers to prevent myopia, office workers, etc.; Single-piece packaging is convenient to carry, when the eyes feel uncomfortable, wear an eye mask or eye mask over the eyes, cool and comfortable immediately relieve eye discomfort; It can be used anywhere, on the subway, on the plane, at the office, at school, at home and so on.

Cooling Fever Patches Color Change Cold Fever Patch

Cooling Fever Patches Color Change Cold Fever Patch

Fever Cooling Patch – Summer Cooling Gel Pads Antipyretic Patches Forehead Cooling Sticker Sheets Suitable for Adults and Children Cooling gel patch for body fever is produced according to TDDS technical. And it is a soft gel strip that has been especially designed to relieve discomfort from baby/child/Adult fevers and other minor ailments with a powerful cooling effect that lasts up to 8 hours. upgrade color change function help to monitor the body temprature change without use thermometer.


Leave Your Message